• Steven Greenberg.
• Respiratory & Immunology, Clinical Research, Merck Research Laboratories, Kenilworth, NJ 07033, USA. steven_greenberg@merck.com
• Curr Opin Allergy Clin Immunol. 2013 Jun 1; 13 (3): 225-36.

Purpose Of ReviewAsthma is a multifaceted disease that is associated with decreased lung function, multiple symptoms, varying levels of asthma control, and risk of acute exacerbations. The ability to predict the risk of developing acute exacerbations may improve the management of asthmatics and facilitate identification of these patients for interventional studies.Recent FindingsFactors that are associated with different manifestations of asthma differ. Biomarkers that are correlated with airways hyper-responsiveness do not necessarily correlate with risk of future exacerbations. Genetic factors that segregate with exacerbation risk are beginning to emerge. Outcome measures that demonstrate predictive validity have been developed and may facilitate patient management and provide novel clinically meaningful endpoints in clinical trials.SummaryThis review will emphasize underlying factors associated with asthma exacerbations and clinical prediction rules that correlate with the risk of developing severe exacerbations of asthma.

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