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Rev. Soc. Bras. Med. Trop. · Mar 2019
Case ReportsFirst case report of cryptococcosis due to Cryptococcus decagattii in a pediatric patient in Argentina.
- Ana Berejnoi, Constanza Giselle Taverna, Mariana Mazza, Matías Vivot, Guillermina Isla, Susana Córdoba, and Graciela Davel.
- Hospital Público Materno Infantil, Salta, Argentina.
- Rev. Soc. Bras. Med. Trop. 2019 Mar 28; 52: e20180419.
AbstractWe report the first case of cryptococcosis due to Cryptococcus decagattii in an immunocompetent pediatric patient from an indigenous community in Argentina with a successful outcome. Two isolates (blood, cerebrospinal fluid) were genotyped by restriction fragment length polymorphism of the orotidine monophosphate pyrophosphorylase (URA5) gene as VGIV and identified by multi-locus sequence typing as C. decagattii. Matrix-assisted laser desorption/ionization time of flight mass spectrometry identification indicated genotype VGIII. The minimum inhibitory concentration of amphotericin B, fluconazole, itraconazole, and voriconazole was determined (cerebrospinal fluid: 0.25, 16, 0.12, and 0.12, blood: 0.25, 4, 0.12, and 0.06, respectively, all in mg/L).
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