• Joshua Wong, Aysegul Gunduz, Jonathan Shute, Robert Eisinger, Stephanie Cernera, Ho Kwo Wei David KWD Center for Movement Disorders and Neurorestoration, Department of Neurology, University of Florida College of Medicine and McKnight Brain Institute, , Daniel Martinez-Ramirez, Leonardo Almeida, Christina A Wilson, Michael S Okun, and Christopher W Hess.
• Center for Movement Disorders and Neurorestoration, Department of Neurology, University of Florida College of Medicine and McKnight Brain Institute, Gainesville, FL, USA.
• Tremor Other Hyperkinet Mov (N Y). 2018 Jan 1; 8: 542.

BackgroundImpedance is an integral property of neuromodulation devices that determines the current delivered to brain tissue. Long-term variability in therapeutic impedance following deep brain stimulation (DBS) has not been extensively investigated across different brain targets. The aim was to evaluate DBS impedance drift and variability over an extended postoperative period across common DBS targets.MethodsRetrospective data from 1,764 electrode leads were included and drawn from 866 DBS patients enrolled in the University of Florida Institutional Review Board-approved INFORM database and analyzed up to 84 months post implantation. An exploratory analysis was conducted to identify trends in impedances using a Mann-Kendall test of trend.ResultsThere were 866 patients and 1,764 leads available for analysis. The majority of subjects had Parkinson's disease (60.7%). The mean age at implantation was 58.7 years old and the mean follow-up time was 36.8 months. There were significant fluctuations in the mean impedance of all electrodes analyzed that largely stabilized by 6 months except for the subthalamic nucleus (STN) target, in which fluctuations persisted throughout the duration of follow-up with a continued downward trend (p < 0.001).DiscussionThe drift in impedance observed primarily within the first 6 months is in keeping with prior studies and is likely due to surgical micro-lesioning effects and brain parenchyma remodeling at the electrode-tissue interface, typically at values approximating 1,000 Ω. The differences in impedance trends over time in the various DBS targets may be due to underlying differences in structure and tissue composition.

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