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Comparative Study
Plasma levels of type II phospholipase A2 and nitrite/nitrate in patients with burns.
- Y Yamada, S Endo, Y Kamei, T Minato, M Yokoyama, S Taniguchi, H Nakae, K Inada, and M Ogawa.
- Critical Care and Emergency Center, Iwate Medical University, Morioka, Japan.
- Burns. 1998 Sep 1; 24 (6): 513-7.
AbstractType II phospholipase A2 (type II PLA2), nitrite/nitrate (NOx), tumor necrosis factor-alpha (TNF-alpha) and endotoxin were studied in burn patients. Type II PLA2 values and NOx values were both significantly higher in the group that died, the group with shock as a complication and the group with multiple organ dysfunction syndrome (MODS) as a complication, than in the group that survived, the group without shock as a complication and the group without MODS as a complication, respectively. The results suggested that type II PLA2 and nitric oxide (NO) may play a major role in the pathology of burn patients. Significant correlations were found between TNF-alpha and type II PLA2 values and between type II PLA2 and NOx values, suggesting the possibility of involvement in each other's production.
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