• J Clin Anesth · Jul 1992

    Case Reports

    Postoperative elevation of serum transaminases following isoflurane anesthesia.

    • J T Gunza and A G Pashayan.
    • Department of Anesthesiology, University of Florida College of Medicine, Gainesville.
    • J Clin Anesth. 1992 Jul 1; 4 (4): 336-41.

    AbstractHalogenated inhalational anesthetics have been implicated in hepatotoxicity. Halothane hepatitis results from the biotransformation of the drug to a metabolite that binds to liver proteins, which creates a hapten, which, in turn, causes an immunologic response in the liver. Case reports of hepatic injury resulting from isoflurane, which has a decreased biotransformation compared with that of halothane, have received much criticism. We describe a patient who had elevated liver enzymes and a positive trifluoroacetyl antibody titer following an anesthetic regimen that included isoflurane.

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