• CMAJ · Sep 2019

    Association of predicted lean body mass and fat mass with cardiovascular events in patients with type 2 diabetes mellitus.

    • Zhenhua Xing, Liang Tang, Jian Chen, Junyu Pei, Pengfei Chen, Zhenfei Fang, Shenghua Zhou, and Xinqun Hu.
    • Departments of Cardiovascular Medicine (Xing, Tang, Pei, Chen, Fang, Zhou, Hu) and Emergency Medicine (Xing), The Second Xiangya Hospital, Central South University, Changsha, Hunan, China; University of South China (Chen), Hengyang, China.
    • CMAJ. 2019 Sep 23; 191 (38): E1042-E1048.

    BackgroundPrevious studies have found that predicted fat mass and lean body mass may act differently on adverse events. However, the cardiovascular prognostic value of lean body mass and fat mass in patients with type 2 diabetes mellitus (T2DM) has not yet been investigated. We sought to investigate the relation between predicted lean body mass or fat mass and the risk of cardiovascular disease in patients with T2DM.MethodsWe conducted a post hoc analysis of data from the Action to Control Cardiovascular Risk in Diabetes (ACCORD) study to investigate the relation between the predicted lean body mass or fat mass and major adverse cardiovascular events in patients with T2DM. We used sex-specific quartiles of predicted lean body mass index (BMI; kg/m2) and fat mass index (kg/m2). We defined a major adverse cardiovascular event as a composite of nonfatal myocardial infarction, nonfatal stroke or death from cardiovascular causes.ResultsAfter a mean follow-up period of 8.8 years, we found that a major cardiovascular event occurred in 1801 of 10 251 patients (17.8%). Predicted lean BMI was not associated with major cardiovascular events (p = 0.34). Compared with patients in the first quartile (incidence rate 16.4%; 17.2%, 17.5% and 19.8% for the second, third and four quartiles, respectively) of predicted fat mass index, those in the fourth quartile had a hazard ratio of 1.53 (95% confidence interval 1.23-1.91).InterpretationIn patients with T2DM, we found that predicted fat mass had a strong positive association with a higher risk of a major adverse cardiovascular event. Increasing lean body mass did not have a protective role. Trial registration: ClinicalTrials.gov., no. NCT00000620.© 2019 Joule Inc. or its licensors.

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