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- Oliver Bogen, Olaf Bender, Pedro Alvarez, Marie Kern, Stefan Tomiuk, Ferdinand Hucho, and Jon D Levine.
- 1 Institut für Chemie und Biochemie, Freie Universität Berlin, Berlin, Germany.
- Mol Pain. 2019 Jan 1; 15: 17448069198745571744806919874557.
AbstractThe size and modular structure of versican and its gene suggest the existence of multiple splice variants. We have identified, cloned, and sequenced a previously unknown exon located within the noncoding gene sequence downstream of exon 8. This exon, which we have named exon 8β, specifies two stop-codons. mRNAs of the versican gene with exon 8β are predicted to be constitutively degraded by nonsense-mediated RNA decay. Here, we tested the hypothesis that these transcripts become expressed in a model of neuropathic pain.
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