• Crit Care · May 2018

    Letter

    Best PEEP trials are dependent on tidal volume.

    • Andrew C McKown, Matthew W Semler, and Todd W Rice.
    • Division of Allergy, Pulmonary, and Critical Care Medicine, Department of Medicine, Vanderbilt University Medical Center, T-1218 MCN, 1161 21st Ave S., Nashville, TN, 37232-2650, USA. andrew.c.mckown@vanderbilt.edu.
    • Crit Care. 2018 May 2; 22 (1): 115.

    AbstractDetermining the optimal positive end-expiratory pressure (PEEP) in patients with acute respiratory distress syndrome remains an area of active investigation. Most trials individualizing PEEP optimize one physiologic parameter (e.g., driving pressure) by titrating PEEP while holding other ventilator settings constant. Optimal PEEP, however, may depend on the tidal volume, and changing the tidal volume with which a best PEEP trial is performed may lead to different best PEEP settings in the same patient.

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