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  • Eur. J. Neurol. · Jan 2015

    Subthalamic deep brain stimulation effects on odor identification in Parkinson's disease.

    • M Fabbri, L C Guedes, M Coelho, D Simão, D Abreu, M M Rosa, L Silveira-Moriyama, and J J Ferreira.
    • IRCCS Institute of Neurological Science, Bologna, Italy; Clinical Pharmacology Unit, Faculty of Medicine, Instituto de Medicina Molecular, University of Lisbon, Lisbon, Portugal.
    • Eur. J. Neurol. 2015 Jan 1; 22 (1): 207-10.

    Background And PurposeOlfactory dysfunction is common in Parkinson's disease (PD) and it is one of the earliest non-motor symptoms. A few studies have suggested that deep brain stimulation of the subthalamic nucleus (STN-DBS) could improve olfactory function. Our aim was to evaluate the acute effect of bilateral STN-DBS on a commonly used smell test in PD patients.MethodsFifteen PD patients who underwent bilateral STN-DBS and 15 controls were recruited. Patients and controls were tested for odor identification.ResultsNo statistical differences were documented between ON and OFF STN-DBS acute stimulation concerning olfaction. Controls presented a better performance for olfactory identification than patients.ConclusionsOur exploratory study did not support that bilateral STN-DBS could have an acute effect on olfactory function in PD patients.© 2014 The Author(s) European Journal of Neurology © 2014 EAN.

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