• Carl-Johan Jakobsen, Rajesh Bhavsar, Dorthe Viemose Nielsen, Pia Katarina Ryhammer, Erik Sloth, and Jacob Greisen.
• Department of Anaesthesiology and Intensive Care, Aarhus University Hospital, Skejby, Aarhus, Denmark. cjj@cale.dk
• J. Cardiothorac. Vasc. Anesth.. 2012 Dec 1;26(6):1039-47.

ObjectiveThe purpose of this study was to evaluate the perioperative cardioprotective effect of high thoracic epidural analgesia (HTEA), primarily expressed as an effect on cardiac performance and hemodynamics in patients undergoing cardiac surgery.DesignA randomized, prospective study.ParticipantsSixty low-to-moderate risk patients between the ages of 65 and 80 years scheduled for elective coronary artery bypass graft surgery with or without aortic valve replacement.SettingA university hospital.InterventionPatients randomized to receive HTEA as a supplement to general anesthesia.Measurements And Main ResultsPerioperative hemodynamic measurements, perioperative fluid balance, and postoperative release of cardiac enzymes were collected. The end-diastolic volume index (EDVI), the stroke volume index (overall 38 v 32 mL), the cardiac index (overall 2.35 v. 2.18 L/minute/m(2)), the central venous pressure, and central venous oxygenation were higher in the HTEA group. The mean arterial blood pressure was marginally lower in the HTEA group, whereas no difference was noted in the heart rate or peripheral saturation between the groups. No differences were found in the postoperative levels of troponin T and CK-MB between groups. NT-proBNP changed over time (p < 0.001) and was lower in the HTEA group (p = 0.013), with maximal values of 291 ± 265 versus 326 ± 274.ConclusionsThe findings of a higher stroke volume index and central venous oxygenation without an increase in heart rate or mean arterial pressure suggest that HTEA improves cardiac performance in elderly cardiac surgery patients.Copyright © 2012 Elsevier Inc. All rights reserved.

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