• Joon-Ho Lee, Woo-Dae Yang, Seong-Yeup Han, Jeong-Il Noh, Seong-Hwan Cho, Sang-Hyun Kim, Won-Seok Chae, and Hee-Cheol Jin.
• Department of Anesthesiology and Pain Medicine, Soonchunhyang University Bucheon Hospital, Gyeonggi-do, Republic of Korea.
• J. Cardiothorac. Vasc. Anesth.. 2012 Dec 1;26(6):1055-9.

ObjectiveThe aim of this study was to determine whether the epidural administration of magnesium during the perioperative period decreased the incidence of chronic postoperative pain (CPOP) at 3 months after video-assisted thoracic surgery.DesignProspective, randomized, and blinded.SettingA university hospital.ParticipantsPatients.InterventionsBefore the induction of anesthesia, the patients were assigned randomly to receive normal saline, 5 mL, (group C, n = 72) or magnesium sulfate, 100 mg (group M, n = 72), epidurally. At the end of surgery, group C received a continuous infusion of a mixture of 0.2% ropivacaine, 226 mL, and fentanyl, 1,200 μg, through a patient-controlled epidural analgesia pump for 48 hours. In group M, magnesium sulfate, 500 mg, was added to the infusion.Measurements And Main ResultsThe incidence and severity of CPOP were assessed by a telephone survey 3 months after surgery. Patients were asked whether they experienced pain and to rank the severity of the pain using a 3-point scale (1, mild; 2, moderate; 3, severe). The incidences of CPOP were 42.4% in group C and 49.1% in group M. The severities of pain in the patients with CPOP were 1.0 (1-2) in group C and 1.0 (1-2) in group M. The incidence and severity of CPOP did not differ between the 2 groups.ConclusionsThe epidural administration of magnesium from before the induction of anesthesia to 48 hours postoperatively did not decrease significantly the incidence or severity of CPOP in patients undergoing video-assisted thoracic surgery.Copyright © 2012 Elsevier Inc. All rights reserved.

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