• J Clin Anesth · May 2020

    Randomized Controlled Trial

    Methadone versus morphine for postoperative pain in patients undergoing surgery for gynecological cancer: A randomized controlled clinical trial.

    • Sebastiano Mercadante, Fabrizio David, Patrizia Villari, Vincenza Manuela Spedale, and Alessandra Casuccio.
    • Anesthesia and Intensive Care Unit, Pain Relief and Palliative Care Unit, La Maddalena Cancer Center, Palermo, Italy. Electronic address: terapiadeldolore@lamaddalenanet.it.
    • J Clin Anesth. 2020 May 1; 61: 109627.

    Study ObjectiveThe aim of this study was to compare methadone and morphine for the management of postoperative.DesignOpen, controlled study.SettingPostoperative recovering area, ward.PatientsSixty-four patients, ASA I-III, undergoing gynecological surgery for cancer.InterventionsMorphine or methadone 0.15 mg/kg given preoperatively. After operation an intravenous morphine or intravenous methadone infusion at doses of 12 mg/day was started.MeasurementsPain intensity and opioid consumption.Main ResultsMethadone infusion provided a better analgesia in comparison with morphine infusion on the second day. Opioid consumption was significantly lower in the methadone group. No episodes of relevant desaturation or signs of respiratory depression were recorded.ConclusionA preoperative bolus of methadone, followed by a continuous infusion of low doses post-operatively, provided a better analgesia, without adding risk of adverse effects, in comparison with morphine.Copyright © 2019 Elsevier Inc. All rights reserved.

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