• Int. J. Antimicrob. Agents · Apr 2012

    Penetration of doripenem in human brain: an observational microdialysis study in patients with acute brain injury.

    • Wolfgang Poeppl, Markus Zeitlinger, Oliver Donath, Gabriele Wurm, Markus Müller, Florin Botha, Udo M Illievich, and Heinz Burgmann.
    • Department of Internal Medicine I, Division of Infectious Diseases and Tropical Medicine, Medical University Vienna, Vienna, Austria.
    • Int. J. Antimicrob. Agents. 2012 Apr 1; 39 (4): 343-5.

    AbstractConcentration-time profiles of unbound doripenem were determined by microdialysis in the cerebral interstitium of five patients with acute brain injury. The ratio of the area under the concentration-time curve in brain to that in plasma (AUC(brain)/AUC(plasma)) was 0.17 in one patient and 0.01 in the remaining four patients. Based on the percentage of the dosing interval during which the doripenem concentration exceeded a certain minimum inhibitory concentration (T>MIC), a value of ≥35% of the dosing interval was reached for pathogens with MICs up to 0.05 mg/L. The present data indicate that breakpoints based on concentrations of doripenem in plasma may overestimate antimicrobial activity in brain parenchyma.Copyright © 2012 Elsevier B.V. and the International Society of Chemotherapy. All rights reserved.

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