• A&A practice · Jan 2020

    Case Reports

    Rapid Induction of Buprenorphine/Naloxone for Chronic Pain Using a Microdosing Regimen: A Case Report.

    • Danny S Lee, Jessica E Hann, Sukhpreet S Klaire, Mohammadali Nikoo, Michael D Negraeff, and Pouya Rezazadeh-Azar.
    • From the British Columbia Centre on Substance Use, Vancouver, British Columbia, Canada.
    • A A Pract. 2020 Jan 15; 14 (2): 44-47.

    AbstractBuprenorphine is an effective treatment for chronic pain and may reduce opioid-induced hyperalgesia. However, its pharmacological properties make its induction challenging, time-consuming, and can precipitate opioid withdrawal. We present the case of a 66-year-old woman with inadequately controlled postoperative pain despite escalating doses of oxycodone and methadone, who was successfully transitioned to buprenorphine/naloxone using a rapid microinduction technique without precipitating opioid withdrawal. Rapid induction provides an alternative method for transitioning patients from other opioids to buprenorphine/naloxone and facilitates transition of patients with chronic pain to buprenorphine therapy within a shorter window compared to currently existing protocols.

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