• Trends Pharmacol. Sci. · Jun 2016

    Andexanet: Effectively Reversing Anticoagulation.

    • Giuseppe Lippi, Fabian Sanchis-Gomar, and Emmanuel J Favaloro.
    • Section of Clinical Biochemistry, University of Verona, Verona, Italy.
    • Trends Pharmacol. Sci. 2016 Jun 1; 37 (6): 413-414.

    AbstractDespite direct oral anticoagulants becoming a mainstay of anticoagulant therapy, the effective, timely, and safe reversal of their anticoagulant effect remains challenging. Emerging evidence attests that andexanet, a recombinant and inactive variant of native factor X (FXa), competitively inhibits and counteracts the anticoagulant effect of many inhibitors of native activated FXa.Copyright © 2016 Elsevier Ltd. All rights reserved.

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