• Tomonori Yamamoto, Yasumitsu Mizobata, Yu Kawazoe, Kyohei Miyamoto, Yoshinori Ohta, Takeshi Morimoto, and Hitoshi Yamamura.
• Department of Traumatology and Critical Care Medicine, Osaka City University, Graduate School of Medicine, Osaka, Japan. Electronic address: m1162149@med.osaka-cu.ac.jp.
• J Crit Care. 2020 Apr 1; 56: 140-144.

PurposeThis study aimed to investigate incidence, risk factors, and outcomes for sepsis-associated delirium (SAD) in mechanically ventilated patients.Materials And MethodsWe performed a retrospective post-hoc analysis of the DExmedetomidine for Sepsis in Intensive care unit Randomized Evaluation (DESIRE) trial. Outcomes included 28-day mortality, ventilator-free days, length of ICU stay, self-extubation, and re-intubation. Multivariable analysis was performed to identify variables independently associated with SAD.ResultsWe retrospectively divided the patients into two groups: delirium group (n = 89) and non-delirium group (n = 98). There were no significant differences between the groups in 28-day mortality, self-extubation, and re-intubation. The number of ventilator-free days was significantly less in the delirium vs. non-delirium group (17 vs. 22 days, p = .006), and the length of ICU stay was significantly longer in the delirium group (10 vs. 5 days, p = .04). Multivariable analyses revealed that emergency surgery, more doses of midazolam, and fentanyl were independent predictors for SAD.ConclusionsSAD was associated with a less number of ventilator-free days and longer length of ICU stay. Emergency surgery, more doses of midazolam, and fentanyl may be independent risk factors for SAD in mechanically ventilated patients with sepsis.Copyright © 2019 Elsevier Inc. All rights reserved.

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