• Journal of neurotrauma · May 2020

    Observational Study

    Chronic hyperglycemia before spinal cord injury increases inflammatory reaction and astrogliosis after injury: human and rat studies.

    • Ki-Su Park, Jin Bum Kim, Martin Keung, Ye Jin Seo, Sung Young Seo, Seul Ah Mun, Young-Seok Lee, Dae-Chul Cho, Jeong-Hyun Hwang, Inbo Han, Chi Heon Kim, and Kyoung-Tae Kim.
    • Department of Neurosurgery, School of Medicine, Kyungpook National University, Daegu, Republic of Korea.
    • J. Neurotrauma. 2020 May 1; 37 (9): 1165-1181.

    AbstractTraumatic spinal cord injury (SCI) can cause permanent disabilities that seriously reduce quality of life. We evaluated the effects of chronic hyperglycemia before SCI on inflammatory markers and functional recovery after SCI in human patients and a rat model. In the human study, multivariate logistical regression analysis revealed that hemoglobin A1c (HbA1c) values, reflecting average plasma glucose concentration over a 3 month period, at admission were a significant risk factor for poor functional recovery. Moreover, patients with chronic hyperglycemia (HbA1c ≥ 6.5%) had high concentrations of inflammatory biomarkers (interleukin [IL]-6 and IL-8) of cerebrospinal fluid after SCI. Consistent with patient findings, chronic hyperglycemia before SCI in rats was associated with increased inflammatory responses and oxygen-free radicals in the spinal cord and blood, thus resulting in poor functional recovery and histological outcomes. Tight glucose control before SCI decreased the harmful effects of hyperglycemia after SCI in both human and rat studies. Our findings suggest that chronic hyperglycemia before SCI may be a significant prognostic factor with a negative impact on functional and histological outcomes, highlighting the importance of tight glucose control before SCI.

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