• Gac Med Mex

    Observational Study

    Pronóstico de pacientes con lupus eritematoso generalizado en una unidad de cuidados intensivos.

    • Silvio Ñamendys-Silva, Miguel Reyes-Ruiz, Eduardo Rivero-Sigarroa, and Guillermo Domínguez Cherit.
    • Secretaría de Salud, Instituto Nacional de Ciencias Médicas y Nutrición "Salvador Zubirán", Departamento de Terapia Intensiva, Ciudad de México, México.

    IntroducciónLa identificación de factores de riesgo para mortalidad ha permitido mejorar el tratamiento de los pacientes críticos con lupus eritematosos generalizado.ObjetivoDescribir las características clínicas y los pronósticos de pacientes graves con lupus eritematosos generalizado ingresados en una unidad de cuidados intensivos.MétodoEstudio de cohorte, observacional y descriptivo. Se incluyeron 207 pacientes con lupus eritematosos generalizado enero de 2011 y enero de 2016.ResultadosDurante el periodo del estudio fueron ingresados 3215 pacientes graves a una unidad de cuidados intensivos, 207 (6.4 %) con lupus eritematosos generalizado después de ser evaluados por un intensivista. La mortalidad fue de 18.4 %. El análisis multivariado identificó la presencia fallas orgánicas (cardiovascular, hepática y neurológica) y niveles séricos de lactato > 2 mmol/L al ingreso o durante las primeras 24 horas de estancia en la unidad de cuidados intensivos como los principales factores asociados con incremento de la mortalidad.ConclusionesUn dato relevante fue que la falla neurológica y la falla hepática estuvieron asociadas con mayor riesgo de muerte a 28 días, sin que identificáramos reportes similares a estos hallazgos.IntroductionIdentification of risk factors for mortality has enabled improving the treatment of critically ill patients with systemic lupus erythematosus.ObjectiveTo describe clinical characteristics and prognoses of critically ill patients with systemic lupus erythematosus admitted to an intensive care unit.MethodProspective, observational cohort study. A total of 207 patients with systemic lupus erythematosus admitted between January 2011 and January 2016 were included.ResultsDuring the study period, 3,215 critically ill patients were admitted to the intensive care unit, out of which 207 (6.4%) were identified as having systemic lupus erythematosus after being evaluated by an intensivist. The multivariate analysis identified the presence of organ failure (cardiovascular, liver, neurological) and serum lactate levels > 2 mmoL/L at admission or within the first 24 hours of intensive care unit stay as the main factors associated with increased mortality.ConclusionsA relevant observation was that neurological failure and liver failure were associated with higher mortality risk at 28 days, without reports similar to these findings being identified.Copyright: © 2018 SecretarÍa de Salud.

      Pubmed     Free full text   Copy Citation     Plaintext  

      Add institutional full text...

    Notes

     
    Knowledge, pearl, summary or comment to share?
    300 characters remaining
    help        
    You can also include formatting, links, images and footnotes in your notes
    • Simple formatting can be added to notes, such as *italics*, _underline_ or **bold**.
    • Superscript can be denoted by <sup>text</sup> and subscript <sub>text</sub>.
    • Numbered or bulleted lists can be created using either numbered lines 1. 2. 3., hyphens - or asterisks *.
    • Links can be included with: [my link to pubmed](http://pubmed.com)
    • Images can be included with: ![alt text](https://bestmedicaljournal.com/study_graph.jpg "Image Title Text")
    • For footnotes use [^1](This is a footnote.) inline.
    • Or use an inline reference [^1] to refer to a longer footnote elseweher in the document [^1]: This is a long footnote..

    hide…

Want more great medical articles?

Keep up to date with a free trial of metajournal, personalized for your practice.
1,624,503 articles already indexed!

We guarantee your privacy. Your email address will not be shared.