• Ioannis Kormpakis, Apostolos Papalois, Panayotis Kinnas, Aristides B Zoubos, Ioannis Sioutis, Anastasia Dimitriadi, Panayotis N Soucacos, and Elizabeth O Johnson.
• Orthopaedic Research & Education Center, Department of Orthopaedic Surg, Greece; Laboratory of Education & Research in Neuroscience (LERNs), Department of Anatomy, National & Kapodistrian University of Athens, Greece. Electronic address: jkormp@gmail.com.
• Injury. 2020 Dec 1; 51 (12): 2879-2886.

AbstractThe way thyroid hormone works in peripheral nerve regeneration has not been fully elucidated, although studies have shown that it has a strong positive effect on nerve regeneration. It is argued that its action is probably stronger than the neurotrophic factors that have been used for some time. It is hypothesized that the use of thyroid hormone in the nerve tubes has a beneficial effect on nerve regeneration to the extent that the results of its use are comparable to those of the autograft technique in bridging small nerve deficits. In this experimental study, we examined the effect of thyroid hormone and BDNF (Brain Derived Neurotrophic Factor) on the repair of 10 mm nerve defects when administered within silicone nerve tubes and compared the results with the autograft method. Thyroid hormone promotes nerve regeneration mainly by increasing its speed and its effect on the maturation of nerve fibers compared to the other groups where the nerve deficit was bridged by entubulation. Also, better organization and the absence of intraneural fibrosis, compared to the other groups, may argue for the action of thyroid hormone in regulating the inflammatory response. Functionally, the AG group showed better results compared to the other groups by the end of the study (16 weeks).Copyright © 2020. Published by Elsevier Ltd.

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