• Methods in enzymology · Jan 2018

    Xenon Anesthesia and CT: Noninvasive Measures of Brain Anesthetic Concentration.

    • Andrew McKinstry-Wu, Charles W Carspecken, Alex Proekt, and Max B Kelz.
    • University of Pennsylvania, Philadelphia, PA, United States. Electronic address: andrew.mckinstry-wu@uphs.upenn.edu.
    • Meth. Enzymol. 2018 Jan 1; 602: 289-298.

    AbstractThe existence of a barrier between anesthetic behavioral state transitions has been observed across phyla, but demonstrating that such a barrier exists and is not a pharmacokinetic artifact has not yet been possible in humans. Such an investigation requires temporally precise information regarding the brain concentration of anesthetic in order to demonstrate the specific pharmacokinetic-pharmacodynamic mismatch that is hysteresis. We propose a method to noninvasively determine brain tissue anesthetic concentration using computerized tomography and the radiopaque gaseous anesthetic xenon. Such a technique can be used to investigate pharmacokinetic-pharmacodynamic mismatches in humans.© 2018 Elsevier Inc. All rights reserved.

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