• Internal medicine journal · Dec 2019

    Case Reports

    RET-rearranged non-small-cell lung cancer and therapeutic implications.

    • Zoe Loh, Paul Mitchell, Thomas John, and Surein Arulananda.
    • Department of Medical Oncology, Olivia Newton-John Cancer Wellness and Research Centre, Austin Health, Melbourne, Victoria, Australia.
    • Intern Med J. 2019 Dec 1; 49 (12): 1541-1545.

    AbstractFirst-line tyrosine kinase inhibitors are standard of care for non-small-cell lung cancers (NSCLC) harbouring an epidermal growth factor receptor mutation, anaplastic lymphoma kinase fusion or c-ros oncogene 1 rearrangement. Other targetable oncogenic drivers have been identified but testing for these is neither funded nor commonly performed in Australia. Using a case example, we discuss the importance of considering several other genomic aberrations in our population, such as rearrangements in the RET proto-oncogene, which occur in 1-2% of lung adenocarcinoma. New oncogenic drivers and corresponding targeted agents are constantly being discovered; these will continue to refine the treatment of non-small-cell lung cancer in the era of precision medicine.© 2019 Royal Australasian College of Physicians.

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