• Eur. J. Intern. Med. · Jun 2019

    Multicenter Study

    Predictive value of serum myostatin for the severity and clinical outcome of heart failure.

    • Pingan Chen, Zhen Liu, Yishan Luo, Lushan Chen, Shaonan Li, Yizhi Pan, Xiaoming Lei, Daihong Wu, and Dingli Xu.
    • Department of Cardiology, Guangzhou First People's Hospital, School of Medicine, South China University of Technology, Guangzhou, China; Department of Cardiology, Guangzhou First People's Hospital, Guangzhou Medical University, Guangzhou, China. Electronic address: cpadejxyx@gzhmu.edu.cn.
    • Eur. J. Intern. Med. 2019 Jun 1; 64: 33-40.

    BackgroundThe exact relationship between serum myostatin and the severity and prognosis of chronic heart failure (CHF) is unclear. In this study, we investigated the association between serum myostatin and the severity and prognosis in patients with CHF.MethodsTwo hundred and eighty-eight CHF patients and 62 healthy controls were studied. Cardiac ultrasound and serum myostatin, N-terminal pro-B-type natriuretic peptide (NT-proBNP) and other parameters were detected. CHF patients were divided into 3 groups according to tertiles of NT-proBNP or myostatin levels respectively.ResultsSerum myostatin levels were higher in CHF patients than in controls. New York Heart Association (NYHA) class IV patients had the highest levels of serum myostatin among the four NYHA classes. Compared with the low tertile NT-proBNP group, serum myostatin levels were significantly higher in the moderate and high tertile groups (15.47 ± 4.25 vs. 14.18 ± 3.69 ng/mL, p = .026; 16.28 ± 5.34 vs. 14.18 ± 3.69 ng/mL, p = .002). During 51-months follow-up, of 173 patients there were 36 deaths. Compared to survivors, nonsurvivors had significantly higher serum myostatin (18.11 ± 4.52 vs. 14.85 ± 5.11 ng/mL, p < .01). Patients in the high tertile myostatin group had lower survival rate (73.95% vs. 93.75%; p < .05) and larger number of CHF rehospitalization than those in the low tertile group. Cox regression analysis showed that serum myostatin was an independent predictor of mortality.ConclusionsSerum myostatin levels can reflect the severity of CHF and be a predictor of adverse prognosis in CHF patients.Copyright © 2019 European Federation of Internal Medicine. Published by Elsevier B.V. All rights reserved.

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