• Nicolas Javaud, Adrien Altar, Olivier Fain, Paul-Georges Reuter, Michel Desmaizieres, Tomislav Petrovic, Aiham Ghazali, Isabelle Durand-Zaleski, Laurence Bouillet, Eric Vicaut, David Launay, Ludovic Martin, Bernard Floccard, Anne Gompel, Alain Sobel, Isabelle Boccon-Gibod, Gisele Kanny, Frederic Lapostolle, and Frederic Adnet.
• AP-HP, Urgences, Centre de référence sur les angiœdèmes à kinines, Hôpital Louis Mourier, Université Paris 7, 92700 Colombes, France; AP-HP, Urgences - Samu 93, Hôpital Avicenne, Université Paris 13, Inserm U942, 93000 Bobigny, France. Electronic address: nicolas.javaud@aphp.fr.
• Eur. J. Intern. Med. 2019 Sep 1; 67: 42-46.

ObjectiveHereditary angiœdema (HAE) is a rare autosomal dominant disease characterized by recurrent, unpredictable, potentially life-threatening swelling. Objective is to assess the management of the acute HAE attacks in the real life setting through a call center in France.MethodsA pre-specified ancillary study of SOS-HAE, a cluster-randomized prospective multicenter trial, was conducted. HAE patients were recruited from 8 participating reference centers. The outcome of interest was the rate of hospitalization.Resultsonerhundred patients were included. The median (quartile) age was 38 (29-53) years, and 66 (66%) were female. Eighty (80%) patients had HAE type I, 8 (8%) had HAE type II and 12 (12%) patients had FXII-HAE. Fifty-one (51%) patients had experienced at least one time the call center during the follow-up. Nine over 166 (5%) attacks for 9 different patients resulted in hospital admission to the hospital (in the short-stay unit, ie, <24 h) during the follow-up period. During 2 years, there were 166 calls to call center for 166 attacks. All attacks were treated at home after call center contact.ConclusionsUse of emergency departments and hospitalizations are reduced by the use of a coordinated national call center in HAE after therapeutic education program that promoted self-administration of specific treatment and use of call to call center.Trial RegistrationclinicalTrials.gov identifier: NCT01679912.Copyright © 2019 European Federation of Internal Medicine. Published by Elsevier B.V. All rights reserved.

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