• Guizuo Wang, Wenli Shang, Yajuan Ren, Sining Liu, Xiaoping Ren, Shenghong Wei, and Dong Han.
• Department of Respiratory and Critical Care Medicine, Shaanxi Provincial People's Hospital, No. 256, West Youyi Road, Xi'an, Shaanxi 710068, PR China.
• Eur. J. Intern. Med. 2019 Dec 1; 70: 39-42.

PurposeThis meta-analysis was performed to evaluate the efficacy of statins in chronic obstructive pulmonary disease (COPD) patients with pulmonary hypertension (PH).MethodsA systematic search was made of MEDLINE, Cochrane, ISI Web of Science and SCOPUS databases. Randomized clinical trials on treatment of COPD-PH with the statins, compared with placebo, were reviewed. Studies were pooled to weighted mean differences (WMD), with 95% confidence interval (CI).ResultsFive trials (enrolling 270 participants) met the inclusion criteria. Compared with placebo, the statins presented significant effects on systolic pulmonary artery pressure (WMD -4.52 mmHg; 95% CI -6.32 to -2.72 mmHg) and 6-min walk distance (6MWD) (WMD 32.46 m; 95% CI 13.63-51.29 m).ConclusionsStatins therapy significantly improves PH and 6MWD in COPD patients with PH.Copyright © 2019 European Federation of Internal Medicine. Published by Elsevier B.V. All rights reserved.

17 keywords...

hide…