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- Nat M J Wright, Alison J Roberts, Victoria L Allgar, Charlotte N E Tompkins, Darren C Greenwood, and Gillian Laurence.
- Centre for Research in Primary Care, Leeds. n.wright@leeds.ac.uk
- Br J Gen Pract. 2004 May 1; 54 (502): 370-3.
AbstractIn December 2000, the Committee for Safety of Medicines (CSM) advised that thioridazine may prolong QT intervals risking arrhythmias. We investigated the impact on general practitioner prescribing of thioridazine using a time series analysis. Numbers of items and costs of antipsychotics and benzodiazepines prescribed in Leeds from May 1999 until April 2002 were collated. Post-advice, thioridazine prescriptions dropped by 810 items per month (95% confidence interval = 420 to 1200, P < 0.001) but others increased slightly in response. Costs mimicked these changes. Fresh criteria are proposed for appraising the quality of evidence needed to inform future urgent facsimile transmissions.
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