• Internal medicine · Apr 2020

    Case Reports

    Hepatitis-associated Aplastic Anemia with Rapid Progression of Liver Fibrosis Due to Repeated Hepatitis.

    • Kenji Sawada, Atsushi Takai, Tomoyo Yamada, Osamu Araki, Yuki Yamauchi, Yuji Eso, Ken Takahashi, Takero Shindo, Takaki Sakurai, Yoshihide Ueda, and Hiroshi Seno.
    • Department of Gastroenterology and Hepatology, Graduate School of Medicine, Kyoto University, Japan.
    • Intern. Med. 2020 Apr 15; 59 (8): 1035-1040.

    AbstractHepatitis-associated aplastic anemia (HAAA) is a variant of acquired aplastic anemia and characterized by bone marrow failure that follows the development of acute hepatitis. We herein report a rare case of HAAA with rapid progression of liver fibrosis due to repeated hepatitis. A pathological examination of liver specimens revealed liver fibrosis progression over a short period. Immunosuppressive therapy with cyclosporine effectively cured both the pancytopenia and hepatitis. Our case suggests that the pathological examination of the liver tissue is useful for determining a treatment plan and that immunosuppressive therapy is a promising treatment for both aplastic anemia and persistent hepatitis.

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