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- Serina Koto, Masataka Umeda, Hiroaki Kawano, Yushiro Endo, Toshimasa Shimizu, Tomohiro Koga, Kunihiro Ichinose, Hideki Nakamura, Akihiro Mukaino, Osamu Higuchi, Shunya Nakane, and Atsushi Kawakami.
- Department of Immunology and Rheumatology, Nagasaki University Graduate School of Biomedical Sciences, Japan.
- Intern. Med. 2020 Apr 15; 59 (8): 109911041099-1104.
AbstractA 58-year-old Japanese woman with herpes zoster developed Behçet's disease (BD) with symptoms including orthostatic intolerance as an autonomic disorder. Multiple immune-suppressive therapies and a β-blocker successfully controlled both the disease activity of BD and the autonomic disorders. A cytokine multiplex analysis of her serum revealed the elevation of proinflammatory cytokines [interleukin (IL)-1, IL-6, IL-12, tumor necrosis factor alfa (TNFα), and interferon gamma (IFN-γ)] and a low IL-10 concentration. IL-10 production is reported to be important for defense against herpes zoster virus (VZV). Insufficient IL-10 production is reported in BD. The reactivation of VZV with this cytokine profile suggests that BD will develop with various symptoms, including severe autonomic disorders.
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