• Medicina · Mar 2020

    Case Reports

    Early Radiation-Induced Sarcoma in an Adolescent Treated for Relapsed Hodgkin Lymphoma with Nivolumab.

    • Lukas Šalaševičius, Goda Elizabeta Vaitkevičienė, Ramunė Pasaulienė, Rosita Kiudelienė, Ernesta Ivanauskaitė-Didžiokienė, Donatas Vajauskas, Nemira Jurkienė, and Jelena Rascon.
    • Faculty of Medicine, Vilnius University, 03101 Vilnius, Lithuania.
    • Medicina (Kaunas). 2020 Mar 31; 56 (4).

    AbstractRadiation-induced sarcoma (RIS) has been reported as a late secondary malignancy following radiotherapy for various types of cancer with a median latency of 10 years. We describe an early RIS that developed in an adolescent within three years of treatment (including PD-L1 check-point inhibitor Nivolumab) of a relapsed classic Hodgkin lymphoma (HL) and was diagnosed post-mortem. The patient died of the progressive RIS that was misleadingly assumed to be a resistant HL based on the positive PET/CT scan. Repetitive tumor biopsies are warranted in cases of aggressive and multi-drug resistant HL to validate imaging findings, ensure correct diagnosis and avoid overtreatment.

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