Gastrointestinal endoscopy
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Gastrointest. Endosc. · Sep 2017
Randomized Controlled Trial Comparative StudyEtomidate versus propofol sedation for complex upper endoscopic procedures: a prospective double-blinded randomized controlled trial.
Although a growing body of evidence demonstrates that propofol-induced deep sedation can be effective and performed safely, cardiopulmonary adverse events have been observed frequently. Etomidate is a new emerging drug that provides hemodynamic and respiratory stability, even in high-risk patient groups. The objective of this study was to compare safety and efficacy profiles of etomidate and propofol for endoscopic sedation. ⋯ Etomidate administration resulted in fewer respiratory depression events and had a better sedative efficacy than propofol; however, it was more frequently associated with myoclonus and increased blood pressure during endoscopic procedures. (Clinical trial registration number: KCT0001701.).