Aging clinical and experimental research
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Unlike Alzheimer's, vascular dementia can, in part, be prevented. The preventive approach foresees treatment for high blood pressure, atrial fibrillation, diabetes, high cholesterol, low HDL cholesterol, sedentary lifestyle, smoking, alcohol abuse, obesity, and sleep apnea. Moreover, also a well-balanced diet and physical activity are cornerstones of prevention, with beneficial effects on the brain and cognition.
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Randomized Controlled Trial
Implications of palonosetron in elderly patients undergoing laparoscopic cholecystectomy with respect to its anti-shivering effect.
The elderly are vulnerable to hypothermia and have a higher risk of cardiovascular events induced by marked increases in oxygen consumption due to shivering. Five-hydroxytryptamine-3 (5-HT3) receptor antagonists have been previously reported to reduce post-anesthesia shivering. ⋯ Pre-operative administration of palonosetron 0.075 mg did not influence perioperative hypothermia or post-anesthesia shivering in elderly patients undergoing laparoscopic cholecystectomy. However, palonosetron might be beneficial for reducing early postoperative pain in elderly patients with opioid-based patient-controlled analgesia.