The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians
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J. Matern. Fetal. Neonatal. Med. · May 2006
Randomized Controlled Trial Comparative StudyA prospective randomized study comparing misoprostol and oxytocin for premature rupture of membranes at term.
The aim of this randomized trial was to compare the efficacy and safety of vaginal misoprostol and oxytocin for cervical ripening and labor induction in patients with premature rupture of membrane (PROM) at term. ⋯ Our study demonstrates that, intravaginally, misoprostol results in a similar interval from induction of labor to delivery when compared to oxytocin.
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J. Matern. Fetal. Neonatal. Med. · Dec 2005
Randomized Controlled TrialA randomized controlled trial of phenobarbital in neonates with hypoxic ischemic encephalopathy.
Phenobarbital is one of the oldest, cheapest and most easily available cerebro-protective drugs for the hypoxic brain. It has multiple actions that could be of benefit to the asphyxiated brain. However, its potential has not been fully explored. ⋯ Phenobarbital in the dose of 20 mg/kg IV given within six hours of life to term and near-term neonates with HIE, significantly decreased the incidence of neonatal seizures and was well tolerated. However, it did not alter the mortality and neurologic outcome at discharge.
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J. Matern. Fetal. Neonatal. Med. · Apr 2003
Randomized Controlled Trial Comparative Study Clinical TrialSpinal and epidural versus general anesthesia for elective cesarean section at term: effect on the acid-base status of the mother and newborn.
To compare general, epidural and combined spinal-epidural anesthesia with respect to short-term outcome of newborns delivered by elective Cesarean section of healthy parturients with normal pregnancies. ⋯ Type of anesthesia does not influence short-term outcomes in infants born via elective Cesarean section, although differences in acid-base status of both the mother and especially the newborn recommend careful use of spinal anesthesia.
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J. Matern. Fetal. Neonatal. Med. · Jun 2002
Randomized Controlled Trial Clinical TrialScreening positive urine pregnancy tests for sexually transmitted diseases expedites the treatment of infected adolescent gravidas.
To test the utility of screening the urine samples used to diagnose pregnancies at urban teen clinics for Chlamydia trachomatis and Neisseria gonorrhoeae by polymerase chain reaction (PCR). We hypothesized that urine screening would increase the proportion of teenagers treated for these two sexually transmitted diseases (STDs) before they initiated pregnancy-related care. ⋯ Screening the urine samples used to diagnose teen pregnancies for two common STDs is a simple, non-invasive procedure that is acceptable to providers and patients, and significantly increases the number of teenagers who are treated for genital infection before they initiate pregnancy-related care.
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J. Matern. Fetal. Neonatal. Med. · Apr 2002
Randomized Controlled Trial Clinical TrialDoes nifedipine prevent the tachysystole associated with misoprostol induction?
To determine the efficacy of oral nifedipine as prophylaxis against uterine tachysystole associated with misoprostol induction of labor. ⋯ Prophylactic oral nifedipine was not shown to decrease the uterine tachysystole associated with vaginal misoprostol induction at a 50-microg dose.