Lancet neurology
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Randomized Controlled Trial Multicenter Study Comparative Study
Efficacy and safety of dexanabinol in severe traumatic brain injury: results of a phase III randomised, placebo-controlled, clinical trial.
Traumatic brain injury is a major cause of death and disability. We sought to assess the safety and efficacy of dexanabinol, a synthetic cannabinoid analogue devoid of psychotropic activity, in severe traumatic brain injury. ⋯ Dexanabinol is safe, but is not efficacious in the treatment of traumatic brain injury.
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Randomized Controlled Trial Comparative Study Clinical Trial
Behavioural intervention for dysphagia in acute stroke: a randomised controlled trial.
Swallowing dysfunction after stroke is common, but there is little reliable evidence for how the disorder should be managed. This study compared standard low-intensity and high-intensity behavioural interventions with usual care for dysphagia. ⋯ These data show a consistent trend towards more favourable outcomes in dysphagic stroke patients who are assigned a standard programme of early behavioural swallowing intervention, including active therapeutic approaches and dietary modification.