Lancet neurology
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Randomized Controlled Trial Multicenter Study Comparative Study
Cilostazol as an alternative to aspirin after ischaemic stroke: a randomised, double-blind, pilot study.
Most patients who have had a stroke are given aspirin; however, aspirin-related cerebral haemorrhage is a complication that is currently of concern, particularly in China where there is a high incidence of cerebral haemorrhage in secondary prevention programmes and within the community. Cilostazol, a phosphodiesterase 3 (PDE3) inhibitor, is an alternative to aspirin that works through a different mechanism. This trial aimed to compare the efficacy and safety of cilostazol with that of aspirin for the long-term prevention of the recurrence of ischaemic stroke. ⋯ National Health Ministry of the People's Republic of China; Otsuka Pharmaceutical.
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Randomized Controlled Trial Multicenter Study
Efficacy and safety of tarenflurbil in mild to moderate Alzheimer's disease: a randomised phase II trial.
The amyloid-beta peptide Abeta(42) has been implicated in the pathogenesis of Alzheimer's disease (AD). We aimed to test the effects of tarenflurbil, a selective Abeta(42)-lowering agent (SALA), on cognition and function in patients with mild to moderate AD. ⋯ Myriad Pharmaceuticals.