Ugeskrift for laeger
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Ugeskrift for laeger · Jun 2007
Review[Cricoid pressure a.m. Sellick in rapid sequence intubation?].
Since Brian Sellick introduced the cricoid pressure in 1961, it has become standard practice for the rapid sequence intubation. The manoeuvre has a high priority and is recommended maintained even during difficult intubation. ⋯ The findings suggest that it may have harmful effects in connection with intubation, laryngeal mask placement and ventilation. In conclusion, it is suggested that cricoid pressure is released in the case of intubation difficulties.
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Toll-like receptors (TLRs) comprise a group of recently discovered receptors which are essential molecular structures in the activation of immunity. The discovery of TLRs has provided a substantial increase in the knowledge of immunologic aspects of disease pathology and is presently giving rise to new treatment strategies. This review summarizes the current knowledge on TLRs functioning in infections, their possible roles in inflammatory bowl disease and the pivotal role for TLRs in endotoxic shock, an area which is currently subject to development of a new farmakon.