African health sciences
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African health sciences · Jun 2020
Effect of interleukins (IL-2, IL-15, IL-18) on receptors activation and cytotoxic activity of natural killer cells in breast cancer cell.
Breast cancer is one of the leading cause of cancer deaths in women. Metastasis in BC is caused by immunosurveillance deficiency, such NK cell maturation, low NK activity and decreasing cytotoxicity. This study was performed to improve activating receptors and cytotoxicity of NK cells using interleukins (ILs). ⋯ IL-2, IL-15, and IL-18 improved activating receptors and proliferation of NK cells. IL-induced NK cells increased TNF-α, IFN-γ, PRF1 and GzmB secretion and cytotoxic activity on BC cells. High NK cell numbers increased BC cell growth inhibition.
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African health sciences · Jun 2020
Implementing electronic health system in Nigeria: perspective assessment in a specialist hospital.
Perspectives on the pioneering work of Electronic Health Recording (EHR) system in Nigeria was studied. ⋯ Health workers were comfortable and satisfied with EHR and it eased their work.Scaling up EHR would reduce administrative cost, transcription errors and paper works to mitigate poor quality data from Nigeria a great contributor to global morbidities/mortalities.
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African health sciences · Jun 2020
Randomized Controlled TrialWeight reduction improves immune system and inflammatory cytokines in obese asthmatic patients.
Activation of immunological and systemic inflammation markers are common in obesity and asthma. ⋯ Weight reduction improved immunological and systemic inflammation markers in obese asthma patients.
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African health sciences · Jun 2020
Meta AnalysisEfficacy and safety of rituximab for systemic lupus erythematosus treatment: a meta-analysis.
Given the inconsistency of previous studies and the newly emerging evidence, we decided to conduct a meta-analysis. ⋯ although the efficacy of rituximab is highly controversial for SLE, our study shows that rituximab presents a satisfying efficacy and safety for SLE.
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African health sciences · Jun 2020
Comparative StudyAnalysis of clinical and virologic features in Hepatitis B e Antigen (HbeAg)-negative and HbeAg-positive Egyptian chronic hepatitis B patients.
HBeAg-negative chronic hepatitis B infection has a divergent clinical course from that of HBeAg-positive infection. ⋯ HBeAg-negative patients compared with HBeAg-positive patients had older age, lower ALT and serum HBVDNA levels, but more incidence of HCC.