African health sciences
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African health sciences · Jun 2020
Bio fabrication of gold nanoparticles and their combination with chemotherapy and ultrasound for effective treatment of tumors.
Chemotherapy is one of the important medical option for the cancer therapy, but still new combination of therapeutic treatment methods are needed to achieve efficient anti tumor activity. In this work, Pueraria lobata leaf extract was utilized as a bio reductant for the fabrication of the Gold nanoparticles (Au-NPs) by an ecological approach without using any harmful chemical. This work also evaluates whether the combined effect of chemotherapy along with Au-NPs and Ultrasound (US) is effective over the tumors or not. ⋯ In conclusion, Pueraria lobata leaf extract mediated synthesis of Au-NPs by an eco-friendly approach was reported in this work. The plant biomolecules of the extract were involved in the reduction and capping of the Au-NPs formed. The major conclusion is that addition of Au-NPs with chemotherapy and ultrasound has shown more effective anti-tumor activity.
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African health sciences · Jun 2020
Randomized Controlled TrialWeight reduction improves immune system and inflammatory cytokines in obese asthmatic patients.
Activation of immunological and systemic inflammation markers are common in obesity and asthma. ⋯ Weight reduction improved immunological and systemic inflammation markers in obese asthma patients.
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African health sciences · Jun 2020
Meta AnalysisEfficacy and safety of rituximab for systemic lupus erythematosus treatment: a meta-analysis.
Given the inconsistency of previous studies and the newly emerging evidence, we decided to conduct a meta-analysis. ⋯ although the efficacy of rituximab is highly controversial for SLE, our study shows that rituximab presents a satisfying efficacy and safety for SLE.
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African health sciences · Jun 2020
Anti-retro viral therapy adverse drug reaction and associated factors among human immuno deficiency virus infected adult patients at Nigist Eleni Mohammed Memorial hospital, South Ethiopia.
Recent increases in access to HAART have made the management of drug toxicities an increasingly crucial component of HIV care in developing countries. The aim of this study was to determine prevalence of antiretroviral therapy adverse drug reactions and associated factors among HIV-infected adult patients at Nigist Eleni Mohammed memorial hospital. ⋯ Nearly one in five patients develop ADRs. Sex of respondents, WHO stage and functional status were associated with ADRs. The health care providers should give due attention to ambulatory, bedridden, and WHO stage III and IV patients.
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African health sciences · Jun 2020
Missed antenatal care follow-up and associated factors in Eastern Zone of Tigray, Northern Ethiopia.
Focused antenatal care improves the survival and health of the mother as well as the babies. However, there are real challenges in keeping the subsequent antenatal care follow up in Ethiopia. Hence, the aim of this study was to assess missed antenatal care follow up and associated factors in the Eastern zone of Tigray. ⋯ The proportion of missed antenatal care follow-up was lessened as compared to local and national evidences. Nevertheless, still a coordinated effort on tracking of pregnant women who missed their antenatal care appointment is required by health policy implementers so as to increase the uptake of four complete visits.