Arthritis research & therapy
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Arthritis Res. Ther. · Apr 2012
Multicenter StudyA multicenter study confirms CD226 gene association with systemic sclerosis-related pulmonary fibrosis.
CD226 genetic variants have been associated with a number of autoimmune diseases and recently with systemic sclerosis (SSc). The aim of this study was to test the influence of CD226 loci in SSc susceptibility, clinical phenotypes and autoantibody status in a large multicenter European population. ⋯ Our data suggest that the tested genetic variants do not individually influence SSc susceptibility but a CD226 three-variant haplotype is related with genetic predisposition to SSc-related pulmonary fibrosis.