JAMA cardiology
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Review
Trends in the Explanatory or Pragmatic Nature of Cardiovascular Clinical Trials Over 2 Decades.
Pragmatic trials test interventions using designs that produce results that may be more applicable to the population in which the intervention will be eventually applied. ⋯ The level of pragmatism increased moderately over 2 decades of CV trials. Understanding the domains of current and future clinical trials will aid in the design and delivery of CV trials with broader application.