Current vascular pharmacology
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Curr Vasc Pharmacol · Jan 2016
ReviewMicrocirculation Alteration and Biomarker Dilemma in Early Septic Shock Diagnosis and Treatment.
Septic shock is represented by severe hemodynamic changes which are manifested with failure of organ systems and high mortality. Early diagnosis together with timely and appropriate treatment is important to attain better outcome. ⋯ It is crucial to improve microvascular perfusion through targeted interventions using patient-centred approach. Moreover, systems biology approach could play a promising role in understanding the immune complexity, characterization of gene expression patterns, and recognition of novel therapeutic targets which could be used as clinical decision making tool in the future.