Nephron. Physiology
-
Nephron. Physiology · Jan 1982
Case ReportsRenal involvement in Wegener's granulomatosis. Report of three unusual cases.
Three patients with rapidly progressive glomerulonephritis due to Wegener's granulomatosis are described. In one patient, acute renal failure was initially the sole manifestation of the disease. Treatment of the two other patients with prednisone and cyclophosphamide resulted in a remarkable recovery of renal function even after a prolonged period of hemodialysis. These cases illustrate that early and sustained treatment with prednisone and cyclophosphamide can restore an adequate renal function in patients with anuria or severe glomerulonephritis due to Wegener's disease.
-
Nephron. Physiology · Jan 1982
Case ReportsHereditary thrombotic thrombocytopenic purpura: microangiopathic hemolytic anemia, thrombocytopenia, and renal insufficiency occurring in consecutive generations.
Microangiopathic hemolytic anemia, thrombocytopenia, and renal insufficiency occurred in a mother an daughter when each was in her third decade. The mother had prominent neurological findings, fever, and expired from renal insufficiency. Her daughter's only major symptom was renal insufficiency. The similarity of the mother's illness to thrombotic thrombocytopenic purpura and of the daughter's to adult hemolytic uremic syndrome suggests that these diseases are variants of a single clinical disorder, while their occurrence in direct descendents strengthens the postulate that in selected instances a genetic predisposition to these disorders may be important.
-
Nephron. Physiology · Jan 1980
Subclavian vein single-needle dialysis in acute renal failure following vascular surgery.
Acute renal failure, following major surgery of the abdominal aorta, was managed in 3 patients using the subclavian vein for single-needle dialysis. Peritoneal dialysis could not be done, as the posterior peritoneum is violated. Blood access for hemodialysis also poses several problems. ⋯ The subclavian vein provides an alternate source of blood supply for single-needle dialysis in these high-risk postsurgical patients who have acute renal failure. Several advantages are described with this technique, including preservation of forearm vessels. Utmost care has to be taken during cannulization of the subclavian vein, as well as meticulous attention given, to prevent infection.