Nephron. Physiology
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Nephron. Physiology · Jan 2012
Review Meta AnalysisRelationship between body mass index and mortality in hemodialysis patients: a meta-analysis.
Previous studies have reported that reduced mortality rates in hemodialysis (HD) patients were negatively related to body mass index (BMI). The potentially protective effect of increased BMI in HD patients has been referred to as 'reverse epidemiology'. Our meta-analysis was conducted to examine the relationship between different BMI ranges and mortality in HD patients. ⋯ High BMI levels were associated with lower all-cause mortality rates in HD patients. It is possible that more stable hemodynamic status, cytokine and neurohormonal alternations contribute to the protective effects of BMI on mortality in HD patients. There is a need for prospective studies to elucidate mechanisms behind this relationship.
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Nephron. Physiology · Jan 2008
Review Meta AnalysisCardiac surgery-associated acute kidney injury: putting together the pieces of the puzzle.
Acute kidney injury (AKI) is a common problem in the context of cardiac surgery. There are both similarities and differences with AKI occurring in other clinical scenarios. In this paper, we discuss those aspects of AKI that are particular to cardiac surgery-associated AKI (CSA-AKI), with emphasis on recent advances in the field. ⋯ CSA-AKI remains a clinically relevant problem for 5-10% of cardiac surgery patients and is associated with adverse clinical outcomes. Small changes in serum creatinine are important and should not be ignored. The overall incidence of new dialysis after cardiac surgery remains low.
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To assess changes in renal vascular resistance (RVR) in human and experimental sepsis and to identify determinants of RVR. ⋯ Changes in RVR during sepsis in humans are unknown. In experimental sepsis, several factors not directly related to sepsis per se appear to influence the RVR. A high cardiac output and the use of large animals predict a decreased RVR, while a decreased cardiac output and the use of small animals predict an increased RVR.