Medicina clinica
-
Standard procedure when treating tetanigenic risk wounds in an emergency room setting, usually includes administering a dose of gamma-globulin or/and a tetanus vaccine. The rapid detection test (Tetanus Quick Stick [TQS]) can better the current procedure of detecting people who are not immunized. Our objective was to review and analyse the validity of the TQS test, and determine the cost-benefit with the data available. ⋯ Sensitivity ranged from 55%-100%, specificity from 66.6%-100%, PPV: 81.1%-100%, NPV: 42.9%-100%. Most of the tests supported the cost-benefit analysis of the TQS test. We determined that in emergency room situations, it would be beneficial to use the TQS test, and an example of good clinical practice.
-
Multicenter Study
Antibody responses to influenza vaccine in patients on biological therapy: Results of RIER cohort study.
Influenza vaccine is recommended for patients with autoimmune inflammatory rheumatic diseases who receive biological therapy. To evaluate if biological therapy impairs immunization after seasonal influenza vaccine. ⋯ Among the patients on biological therapy vaccinated against influenza, anti-TNF therapy was identified as a predictive factor of final seropositivity. Rituximab presented a lower rate of final seropositivity, which could be increased with an accurate administration schedule.