Expert opinion on drug safety
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Expert Opin Drug Saf · Jul 2010
Meta AnalysisSafety and tolerability of duloxetine in the acute management of diabetic peripheral neuropathic pain: analysis of pooled data from three placebo-controlled clinical trials.
Summarize safety and tolerability of duloxetine in treating diabetic peripheral neuropathic pain. ⋯ Duloxetine was generally safe and well tolerated, with the three most commonly reported TEAEs being nausea, somnolence and constipation. Modest changes in glycemia were associated with duloxetine. Aspartate transaminase/alanine transaminase increases were transient and not considered predictive of more severe outcomes.