Expert opinion on drug safety
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Expert Opin Drug Saf · Oct 2015
Review Meta AnalysisRisk of elevated transaminases in cancer patients treated with immune checkpoint inhibitors: a meta-analysis.
This meta-analysis has been conducted to determine the risk of elevated transaminases associated with immune checkpoint inhibitors use in patients with cancer. ⋯ Our study has shown that the use of immune checkpoint inhibitors has a causal relationship to an increased risk of high-grade elevated ALT and AST. Clinicians using these agents should be attentive of this risk.