Journal of pharmacological sciences
-
Comparative Study
Noxious stimuli evoke a biphasic flexor reflex composed of A delta-fiber-mediated short-latency and C-fiber-mediated long-latency withdrawal movements in mice.
The nociceptive flexor reflex was studied in mice, focusing in particular on movement. Electrical stimuli delivered to the ventral aspect of the toe through a pair of needle electrodes inserted subcutaneously elicited a biphasic withdrawal reflex that was composed of short- and long-latency movements of the ipsilateral hind paw. The first response had a lower activation threshold compared with the second movement. ⋯ Thus, simultaneous activation of Adelta- and C-fibers leads to separate, but sequentially occurring withdrawal movements of the hind paw in mice. Systemic administration of morphine suppressed the withdrawal reflex, which was attributable to a preferential reduction of the Adelta-fiber-mediated short-latency component. This method will be useful for understanding how Adelta-fiber- and C-fiber-mediated nociceptive reflexes are affected by drugs in the whole animal system.