Revista da Associacao Medica Brasileira (1992)
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Rev Assoc Med Bras (1992) · Apr 2022
Ozone combined with doxorubicin exerts cytotoxic and anticancer effects on Luminal-A subtype human breast cancer cell line.
We aimed to examine the potential anticancer effects of ozone applied after chemotherapeutic treatment with different concentrations of doxorubicin in Luminal-A subtype of human breast cancer cell line (MCF-7) and compare the results with effects on L929 fibroblast cell line. ⋯ Ozone treatment potentiated the apoptotic and anticancer activities of doxorubicin in MCF-7 cells and showed repairing and healing effect on healthy fibroblast cells, which were damaged from cytotoxic effects of chemotherapeutic agent. MCF-7 cells may acquire sensitivity against the doxorubicin combined with ozone treatment through activating tumor necrosis factor alpha, MMP-2, and MMP-9 expressions.
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Rev Assoc Med Bras (1992) · Apr 2022
Tumorigenic and immunological roles of Heat shock protein A2 in pancreatic cancer: a bioinformatics analysis.
Heat shock protein A2 has been reported to be tightly associated with tumorigenesis and tumor progression. This study aimed to determine the oncogenic and immunological roles of Heat shock protein A2 in pancreatic cancer by bioinformatics. ⋯ Heat shock protein A2 is upregulated in pancreatic cancer and is closely associated with tumor immunity and aggressive progression.
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Rev Assoc Med Bras (1992) · Apr 2022
Parenthood experiences of LGBT+ individuals: a systematic review.
This systematic review aims to analyze the parenthood experiences of LGBT+ individuals. ⋯ Compared to the heterosexual parents, LGBT+ individuals faced with various problems in their social, family, and professional lives during parenthood. Therefore, they need more family, legal, and social support.