Revista da Associacao Medica Brasileira (1992)
-
Rev Assoc Med Bras (1992) · Jan 2024
Biochanin A restored the blood-brain barrier in cerebral ischemia-reperfusion in rats.
Blood-brain barrier is a protective layer that regulates the influx and efflux of biological materials for cerebral tissue. The aim of this study was to investigate the effects of Biochanin A on cerebral histopathology and blood-brain barrier immunohistochemically. ⋯ Cerebral ischemia-reperfusion caused an increase in oxidative stress and pathological lesions in the cerebrum. Biochanin A treatment restored the adverse effects of ischemia-reperfusion injury by restoring blood-brain barrier.