Revista da Associacao Medica Brasileira (1992)
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Rev Assoc Med Bras (1992) · Oct 2016
Review Case ReportsFetal thrombotic vasculopathy: A case report and literature review.
Fetal thrombotic vasculopathy is a recently described placental alteration with varying degrees of involvement and often associated with adverse perinatal outcomes. The diagnosis is made histologically and therefore is postnatal, which makes it a challenge in clinical practice. ⋯ The fetal thrombotic vasculopathy may be associated with adverse perinatal outcomes including fetal death, but much remains to be studied regarding its pathogenesis. Diagnosis during pregnancy is not possible and there is still no proven treatment for this condition. Future studies are needed so that strategies can be developed to minimize the impact of fetal thrombotic vasculopathy.
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Rev Assoc Med Bras (1992) · Oct 2016
Interest in research among medical students: Challenges for the undergraduate education.
In recent decades, there has been a reduction in the number of graduates from medical schools who choose to pursue a career in scientific research. That has an impact on the profile of graduates, since medical education depends on understanding the formation of scientific evidence. The construction of new knowledge is also hampered by the reduction of medical scientists, whose clinical experience with patients provides an essential step towards medical Science evolution. ⋯ Although interest in research is clearly present among the students, this is still an underexplored element among the population studied. The incorporation of research in the learning process depends on stimulus and guidance until it becomes culturally consolidated as an essential element of the medical training.
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Rev Assoc Med Bras (1992) · Oct 2016
Application of prognostic score IPSET-thrombosis in patients with essential thrombocythemia of a Brazilian public service.
In patients with essential thrombocythemia (ET), the vascular complications contribute to morbidity and mortality. To better predict the occurrence of thrombotic events, an International Prognostic Score for Thrombosis in Essential Thrombocythemia (IPSET-thrombosis) has recently been proposed. We present the application of this score and compare its results with the usual classification system. ⋯ Cardiovascular risk factors and leukocytosis were directly associated with arterial thrombosis. IPSET-thrombosis appears to be better than the traditional classification at identifying lower risk patients who do not need specific therapy.
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Rev Assoc Med Bras (1992) · Oct 2016
Outcomes of allogeneic stem cell transplantation among patients with acute myeloid leukemia presenting active disease: Experience of a single European Comprehensive Cancer Center.
Allogeneic hematopoietic stem cell transplantation (ASCT) representes a potentially curative approach for patients with relapsed or refractory acute myeloid leukemia (AML). We report the outcome of relapsed/refractory AML patients treated with ASCT. ⋯ In our cohort, TRM in first years after ASCT remains considerable, but ASCT in this setting seems to be a good choice for AML patients with active disease. However, novel approaches are needed to reduce TRM and relapse in this set of patients.
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Rev Assoc Med Bras (1992) · Sep 2016
Maternal depression and child development: Evidence from São Paulo's Western Region Cohort Study.
While a growing body of evidence has investigated the relationship between maternal mental health and child development, evidence on children's early life outcomes remains mixed. We analyze the empirical relationship between maternal depression and children's development at age one using data from the São Paulo Western Region Cohort project. ⋯ The results from this study suggest that symptoms of maternal depression are not associated with delays in child development in the study setting analyzed. Further research will be needed to understand this lack of association: while it is possible that caregivers' mental health did not affect caregiving behavior, it is possible that the effect of maternal depression can vary according to timing, persistence, and intensity. It is also possible that the EPDS instrument may fail to identify mothers with clinical depression, or that children with depressed mothers get increased support from other family members or public early childhood focused programs.