Revista da Associacao Medica Brasileira (1992)
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Rev Assoc Med Bras (1992)
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Rev Assoc Med Bras (1992) · Nov 2010
Review[The molecular basis of RH system and its applications in obstetrics and transfusion medicine].
The Rh system is the most polymorphic and immunogenic for all blood group systems. Currently more than 49 antigens were identified with five major antigens D, C, c, E, e. ⋯ In Caucasians the primary mechanism of Rh-negative phenotype is the complete RHD gene deletion, while in African descendants it is the presence of pseudogene and gene RHDψ hybrid RHD-CE (4-7)-D. The authors analyze the structure of the Rh complex in red cells, molecular basis of the Rh system, mechanisms of Negativity RHD and weak and incomplete expression of RHD.