Revista da Associacao Medica Brasileira (1992)
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Rev Assoc Med Bras (1992)
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Rev Assoc Med Bras (1992) · Nov 2017
Meta AnalysisAssociation between the RAGE (receptor for advanced glycation end-products) -374T/A gene polymorphism and diabetic retinopathy in T2DM.
Interaction between advanced glycation end-products (AGEs) and receptor for AGEs (RAGE) in cells could affect both extracellular and intracellular structure and function, which plays a pivotal role in diabetic microvascular complications. The results from previous epidemiological studies on the association between RAGE gene -374T/A polymorphism and diabetic retinopathy (DR) risk were inconsistent. Thus, we conducted this meta-analysis to summarize the possible association between RAGE -374T/A polymorphism and DR risk. ⋯ This meta-analysis reveals that the A allele of RAGE -374T/A polymorphism probably increase DR risk.